Obesity is a pathology that is already pandemic.
At the origin of an excessive consumption of food there are the cerebral circuits of hedonism, those which bring to eat for the pleasure beyond satiety. These are possibly the same brain regions involved in the consumption of tobacco, alcohol and drugs.
These neural systems (which contain dopamine) include the nucleus accumbens, the dorsal striatum, the ventral tegmental area and the orbitofrontal cortex. The dorsolateral prefrontal cortex (DLPFC), which is connected with the aforementioned regions, exerts a cognitive control (reappraisal) on pleasure-oriented behaviors. Direct stimulation of DLPFC by transcranial repetitive magnetic stimulation (rTMS) can reduce impulsive behavior which are food-oriented. The rTMS has very few contraindications and almost no side effects (see our website www.neurolacote.ch for more information). There are already several studies that show that rTMS stimulation of the DLPFC suppresses appetite in comparison to controls that undergo phantom stimulation (placebo). Several rTMS sessions should lead to a stable reduction of appetite and weight. We can perform rTMS treatment in our center if the patient already has a specialized medical follow-up for obesity.
Lowe CJ et al. Neuroimage 2018, 177,45-48.
Kim SH et al. Brain Stimulations 2018, 528-535.